Bruce R. Donald

Research Interests:

Computational Biology, Computational Chemistry, Structural Biology, Biochemistry, Protein Design, Drug Design, NMR of Biological Macromolecules, Microelectromechanical Systems (MEMS), Micro-robotics, Geometric Algorithms

Specialties:

Artificial Intelligence

Courses Taught:

• COMPSCI 590.01 - ADVANCED TOPICS IN CPS

Representative Publications: (More Publications)

• I. Georgiev and R. Lilien and B. R. Donald, Improved Pruning Algorithms and Divide-and-Conquer Strategies for Dead-End Elimination, with Application to Protein Design, Bioinformatics, vol 22 no. 14 (2006), pp. e174--183.
• B. Stevens and R. Lilien and I. Georgiev and B. R. Donald and A. Anderson, Redesigning the PheA Domain of {Gramicidin Synthetase} Leads to a New Understanding of the Enzyme's Mechanism and Selectivity, Biochemistry (2006).
• L. Wang and R. Mettu and B. R. Donald, A Polynomial-Time Algorithm for {\em de novo} Protein Backbone Structure Determination from NMR Data, Journal of Computational Biology, vol 13 no. 7 (2006), pp. 1276--1288.
• S. Potluri and A. Yan and B. R. Donald and C. Bailey-Kellogg, A Complete Algorithm to Resolve Ambiguity for Inter-subunit NOE Assignment in Structure Determination of Symmetric Homo-oligomers, Protein Science (2006).
• S. Potluri and A. Yan and and J. J. Chou and B. R. Donald and C. Bailey-Kellogg, Structure Determination of Symmetric Homo-oligomers by a Complete Search of Symmetry Configuration Space Using NMR Restraints and van der Waals Packing, Proteins: Structure, Function and Bioinformatics, vol 65 no. 1 (2006), pp. 203--219.